1 . 永久性损坏

生物科技行业专业英语第996页 ... 永久性成分 permanent member 永久性损坏irremediable defect 用环组成的 annulate.

1 . 现在是无法补救

The evil is now irremediable ., 这种不幸现在是无法补救了.

1 . 挽回的悲剧

for both of them , it was an irremediable tragedy which could not be simply wrapped by the word Eventuality .对他们来说，这是一场无法挽回的悲剧，而这场悲剧终究不是“偶然”这个词就可以简单概括的。

1 . 不可收拾的局面

being punished while making mistake is perfectly justified . conniving at blunder even crime may result in irremediable complexion .犯了错误受到惩罚是天经地义的。纵容犯错甚至犯罪，可能会导致不可收拾的局面。